Dr. O’Keefe is a board certified orthopedic surgeon with over 15 years of experience in minimally invasive joint replacement including direct anterior hip replacement, knee and shoulder replacement. His expertise includes standard and reverse shoulder replacement as well as partial knee replacement.
Dr. O’Keefe also specializes in arthroscopic procedures of the shoulder and knee including rotator cuff repair and labral repair as well as ACL reconstruction and meniscus repair. In addition, Dr. O’Keefe practices a breadth of general orthopedics including fracture care, hand surgery and foot and ankle care.
Dr. O’Keefe began his training at Macalester College in St. Paul, Minnesota. He graduated with a degree in Biology. He then attended the University of Minnesota Medical School in Minneapolis, Minnesota. Dr. O’Keefe spent two years of Medical School participating in a Graduate Assistantship in the Department of Orthopedic Surgery.
During Medical School, Dr. O’Keefe earned several honors including a RAVITCH Scholarship from the Minnesota Medical Foundation, a Park Nicollet Clinic Scholarship Award and participated in research earning a Minnesota Medical Foundation research grant resulting in two publications in cancer research. These articles were published in Nature Medicine and the Journal of Orthopaedic Surgery.
Following Medical School, Dr. O’Keefe completed his internship and residency at Loyola University Medical Center in Chicago, Illinois. Here he received comprehensive training in the latest surgical techniques including direct anterior hip replacement and advanced arthroscopic techniques. In addition, Dr. O’Keefe received extensive training in fracture care, hand surgery and general orthopedics. Dr. O’Keefe completed his residency having completed nearly 1400 cases.
With extensive exposure to orthopedic trauma care, Dr. O’Keefe spent time in Ho Chi Minh, Vietnam at The Hospital for Traumatology and Orthopaedics participating in orthopedic trauma cases.
In addition to the comprehensive specialized training Dr. O’Keefe acquired, he utilizes over 15 years of clinical experience to provide the best individualized care to each and every patient. His goal is to maximize function and quality of life for those he treats in his practice.
Elbow Care, including Treatment of Tennis/Golfer’s Elbow, Distal Bicep and Tricep Injuries, Treatment of the Overhead Athlete including Ligament, Tendon, Cartilage, and Traumatic Injuries. Procedures Performed include Osteochondritis Dissecans (OCD) Treatment, Biceps and Triceps Tendon Repair, and Open and Arthroscopic Treatment of Tennis Elbow. Dr. O’Keefe also utilizes PRP injections as an option for recalcitrant tennis elbow.
Hip Care, including Direct Anterior Hip Replacement. This is a minimally invasive, muscle sparing technique that can speed recovery.
Knee Care, including Treatment of ACL Injuries, Meniscus Injuries, Patellar Instability, Chondral Injuries, Quadriceps and Patellar Tendon Injuries and Knee Arthritis. Procedures include Knee Ligament Reconstruction (including ACL Reconstruction), Articular Cartilage Repair, Meniscus Surgery, and Partial and Total Knee Replacement. This includes patient specific Partial and Total Knee Replacement.
Shoulder Care, including Treatment of Shoulder Instability/Labral Injuries, Shoulder Separation Injuries, Proximal Bicep Tendon Injuries, Rotator Cuff Tears and Osteoarthritis of the Shoulder. Procedures include Total and Reverse Shoulder Arthroplasty, Shoulder Arthroscopy, Labral Repair, Rotator Cuff Repair, Treatment of Shoulder Instability, AC Joint and CC Ligament Reconstructions and Treatment of SLAP Tears
Sports Medicine, including Non-Surgical and Surgical Treatment of a Broad Range of Sports Injuries in Athletes of All Ages
Pediatric Care, including Treatment of Upper and Lower Extremity Sprains/Strains, Sport Injuries and Common Fracture Care
Hand & Wrist Care, including Treatment of Common Fractures, Trigger Finger, Ganglion Cysts and Carpal Tunnel Syndrome, Thumb Joint Replacement, Tendinitis, Fingertip Injuries
Ankle Care, including Treatment of Common Fractures, Ligament Injuries, Instability, Cartilage Injuries and Tendon Injuries
Fracture Care, including Treatment of Common Orthopedic Fractures involving the Knee, Hip, Shoulder, Ankle, Elbow and Wrist
Board Certified, American Board of Orthopaedic Surgery
Loyola University Medical Center, Illinois
University of Minnesota, Twin Cities
Hospital & Surgery Center Affiliations
Blaine Orthopedic Surgery Center
Mercy Same Day Surgery Center and Hospital
North Memorial Ambulatory Surgery Center at Maple Grove
American Academy of Orthopaedic Surgeons, Board Certified (2010)
Research & Publications
Dr. O’Keefe has contributed to some excellent publications throughout his career.
June 30, 2021
My whole experience with TCO has been great. From the doctor visits before and after surgery, to physical therapy, the entire staff took an interest in me and my recovery. When it comes time to fix my other knee, I will be back! Thank you Dr. O’Keefe and Dalton.
May 28, 2021
I had outstanding care. Dr. O’Keefe and Dalton, PA-C always took time to answer all of my questions and in a way that was easy to understand. I always felt they were truly interested in giving me the best care possible. Thanks much!
May 27, 2021
I first came to TCO for a cortisone shot in my right shoulder, due to a bicycle accident which happened years before. I was treated for this at another facility and the shots provided no relief. I have now had two shots at TCO and both gave me relief for almost two years, each time. I started having wrist pain in my left wrist and was diagnosed with inflammed tendons. I was given a shot and told that if it doesn’t work well, I will need surgery. Ultimately surgery had to be done with Dr. O’Keefe. I am one week post-op now. I have no pain and my range of motion is returning.
May 21, 2021
I have been seeing Dr. O’Keefe for several years. In 2012 he fixed my broken femur, which is doing great. I have always had great confidence in him and when he did my knee, he did not disappoint. Before my surgery, I felt well informed and well prepared. The pre-surgery class at Mercy Hospital was so helpful. After my surgery, I had severe muscle cramps and nausea. Dalton, his PA-C, and the nurses worked very hard at figuring out a combination of meds that finally kept both things at bay. Courtney and Marie in PT have been fantastic. They led me and gently pushed me to keep gaining strength and mobility. I feel very much “back to normal” and I couldn’t be happier.
May 14, 2021
I have no pain after surgery with Dr. O’Keefe. All is well!
May 11, 2021
Great job by Twin Cities Orthopedics staff and Dr. O’Keefe! I tore my meniscus and they had me back up and moving right away. Thank you for the great experience and for treating me like I was your #1 priority!
Dr. O’Keefe and TCO staff do excellent work. I am extremely satisfied and wish I had done this sooner.
May 7, 2021
I had a great experience. Dr. O’Keefe made my first surgery go great! Everyone at TCO is extremely helpful and was awesome. Thank you!
May 4, 2021
It’s been 3 months since my shoulder replacement and it’s been awesome. From surgery to physical therapy, things went well and I’ve had less pain each day. Shout out to Ron Fisher (you’re awesome), Dalton Niel, PA-C (thank you), and Dr. O’Keefe (best surgeon ever)!
April 29, 2021
My experience with Dr. O’Keefe and at TCO has been great! From the team of doctors to physical therapists, they have been top notch. They are very attentive to patient needs and are very caring. I highly recommend TCO Otsego!
April 25, 2021
Dr. O’Keefe did a great job on both of my hip replacements!
November 20, 2020
Dr. O’Keefe did such a great job on my operation. I am very satisfied with his work. I appreciate that he did such great work since it makes my life a lot easier now. I’m so glad I had him as my doctor. Thank you, thank you, thank you!
September 3, 2019
Both procedures went extremely well. Dr. O’Keefe and the rest of the staff were unbelievably kind and friendly. I was shocked with the low level of discomfort I felt and how quickly I recovered. Anyone with a joint problem needs to come here and take care of it. Thank you to all that helped me through this.
August 12, 2019
This is my third procedure through TCO with Dr. O’Keefe, this time being a complete replacement of my right shoulder. He is my orthopedist. I have been thoroughly pleased with my care here in the hospital, clinic and physical therapy. Dr. O’Keefe and staff have instilled confidence about my expected results. My results have been great and have returned me to my normal tasks and certainly improved my quality of life.
August 12, 2019
I was treated with total respect by Dr. O’Keefe. Every staff member was helpful, happy and a pleasure to be around. I can’t believe how great I feel. Why did I wait so long to feel so great? The personal care was outstanding!! THANK YOU!
July 9, 2019
The service with Dr. O’Keefe was excellent. I didn’t have long waits for anything. The surgery went well, the recovery and therapy gave me great results. My hand does not cause me pain at all anymore. I would do it again in a heartbeat.
June 21, 2019
My experience with Dr. O’Keefe was life changing! I can walk for miles with no pain.
June 21, 2019
From the very start in the exam room, Dr. O’Keefe was very helpful. The “schooling” before the procedure was beneficial (don’t skip this). The day of the procedure, everyone involved was very nice. The recovery suites were topnotch – I wanted to stay longer. PT was awesome with Ron at TCO – Otsego. Follow-up appointments (for x-rays four weeks after) were easy to make. I am so happy that I did the procedure and I would recommend TCO and Dr. O’Keefe to all my friends and family.
April 18, 2019
Once I decided to finally address the pain in my knee, I was getting injections. Decided to go all the way (tired of injection shots) and get my knee replaced. Dr. O’Keefe was open with me, informing me on what to expect. All went as he had told me it would and now the knee feels much better. Will be great to be able to do activities without pain.
April 10, 2019
I had a good experience with Dr. O’Keefe and TCO. I was well informed on how things would progress and all staff was pleasant to work with.
April 8, 2019
Right shoulder is perfect. Dr. O’Keefe is an excellent surgeon. I will be having him do my left shoulder in the near future. Recovery was easy.
April 8, 2019
First things first, when you’re told to do your exercises, do them! Dr. O’Keefe is very straight forward, yet very compassionate. Nathan is compassionate as well. I’m three months post hip replacement surgery and am getting better each day thanks to these two professionals. TCO is blessed to have them and if I should ever need surgery again, I’ll choose them.
Dr. O’Keefe and physical therapist Ron are fantastic. The EXCEL Program was awesome. All knee professionals and billing wasn’t confusing (very simple). Everything scheduled with therapy was very organized. They made me feel comfortable and confident that everything was well planned.
March 15, 2019
I blew out my ACL and it took my meniscus out with it. When recovering, the biggest thing I worked on was range of motion. 9 months after I was okayed to go skiing.
March 15, 2019
My worn-out right hip was making my back and neck ache from overcompensating when shifting my weight and force to my left leg. 3 months prior to surgery I was not able to run or climb stairs. Now, 6 weeks after knee replacement surgery with Dr. O’Keefe, I am walking with ease and stairs are no longer a challenge. I’m ready to get into strength training and swimming. I really look forward to riding my horses in another 2 months.
March 1, 2019
Before surgery I had, at times, severe pain in both my knee and hip. I was unable to do stairs without feeling pain. Now I can run down them pain free. Thanks Dr. O’Keefe!
February 28, 2019
Everything went great! I wouldn’t think twice about doing it again. Pain free! Both Dr. O’Keefe and Nathan Dumm were wonderful. I would never consider going anywhere else.
February 28, 2019
Had scope surgery 1st but didn’t help much, then the knee replacement surgery by Dr. O’Keefe went well and the knee feels much better now.
February 28, 2019
I would recommend Dr. O‘Keefe and Nathan to my friends and family. Dr. O’Keefe and Nathan were very informative on how the surgery was needed, my right thumb didn’t respond to the shots anymore. Surgery went well and PT has gone really well. They have been complemented by other surgical results. Little or no pain. Do what the Dr. says and the results are great!
August 8, 2018
Dr. O’Keefe first operated on me when I broke my elbow in a bicycle accident. He was successful in putting my shattered elbow back together. I also have seen him for a knee problem over the last few years. After injections did not solve the problem, I had a total knee replacement that was very successful. I appreciated the fact that he let me make the decisions on how to proceed. I highly recommend Dr. O’Keefe as an orthopedic surgeon.
August 8, 2018
From the moment I met Dr. O’Keefe I felt comfortable. He was professional, thorough and readily answered any questions. I was a very apprehensive patient in making the decision to have a knee replacement. Dr. O’Keefe understood that and reassured me through his calm presence during my pre-op appointment and throughout the surgical process. Most importantly the surgery went great and recovery was as expected. I’m very excited to have my mobility back and feel grateful to Dr. O’Keefe and his staff.
June 1, 2018
GREAT success with my total shoulder replacement done by Dr. O’Keefe. Perfect results and the care given from making the first appointment through PT was top notch. If there is any advice I would give it would be DON’T WAIT to have it done. I am pain free!
October 24, 2017
Twin Cities Orthopedics,
I had my left hip totally replaced on March 20th, 2017. This was my second hip replacement, and I was invited to participate in the EXCEL program at TCO, where I would be having my surgery and recovery done in a non-hospital setting. It was a great way to get this done. My surgery was scheduled early in the morning at the surgery center, and after coming out of the anesthesia, I was brought by van to an assisted living facility. There, I had a room to myself with my care giving staff in the room next to mine. They provided excellent around the clock care including checking on my well being and physical therapy sessions. I was ready to go home by 11:00am the very next day.
The staff members I came into contact with through the entire process were all great! Very professional and caring people that were, in my opinion, some of the best care givers out there. I had Dr. O’Keefe as my surgeon and he did a great job with my hip replacement (he had done my right hip back in 2014 as well).
I’d surely recommend the EXCEL program for anyone qualified to do it. For me, it was a great way to get my hip replacement done. I’m enjoying being able to do the activities I enjoy a lot more comfortably now.
July 21, 2017
I wanted to commend your providers and their excellent staff at your Elk River location. Michael Mastous and Dr. O’Keefe treated my son Liam after a break to both bones in his arm just below the wrist. Liam is a freshman at Elk River High School, and during practice, he suffered a break during a rebounding drill that we all thought would require surgery. It was about 4:00 pm when the break occurred, and I thought your Elk River location accepted walk-ins. When I arrived, the staff politely explained that this was not a walk-in clinic, but they would ask Mike if he would see Liam anyway. Fortunately, Mike and the staff agreed, knowing treating Liam would require them to stay at the office late. After the confirmation via x-ray that both bones were broken, Mike explained that surgery was 50-50 proposition, and regardless, manipulation would be required to splint the arm. Mike diligently proceeded with his staff to manipulate and mobilize the arm via splint. They all assured Liam (who was feeling more depressed than the pain in his arm) that whether surgery, or, if by chance the manipulation lined the bones up properly and surgery could be avoided, that his arm would be fixed. Upon one-week follow-up with Dr. O’Keefe, he showed us and explained that the manipulation lined up the bones perfectly, but, he didn’t want to remove the splint until more healing took place. Dr. O’Keefe was fairly confident that surgery could be avoided.
Surgery was avoided, and at this point in time, the cast is off and Liam is starting to dribble with his left hand. For a kid that practices no less than 2 hours a day, and loves basketball, the care your team provided was not only exemplary, it assured a young man that this was just a small bump in the road. Please extend my sincere gratitude to your fine staff at Elk River, and know that Twin Cities Orthopedics is my only recommendation for Elk River High School athletes who may suffer these types of injuries. Further, in my duties as a high school basketball, football and lacrosse official, I will communicate the fine care we personally experienced at TCO.
– Chris C (Liam’s Father)
May 5, 2017
I was referred to Dr. O’Keefe by my primary physician because I was having issues with my right hip. Dr. O’Keefe performed a physical and did x-rays and it was determined that I should have the hip replaced. There was no pressure from him. He said I would know when the time was right. He performed the surgery almost a year ago and I have been very happy with how my recovery has gone. Thank you very much Dr. O’Keefe and staff for your assistance.
May 5, 2017
If you are looking for a straight forward, direct response to your questions and treatment, Dr. O’Keefe is the orthopedist for you. His treatment of and eventual replacement of my knee were fully explained, options considered and decisions made together. I highly recommend Dr. O’Keefe, his support staff, and therapists. My journey to knee replacement recovery was seamless due to the care and concern of this team. I recommend Dr. O’Keefe to anyone who asks about my knee/surgery.
March 10, 2017
After experiencing severe pain in my right hip, I met with Dr. O’Keefe and he advised cortisone shots which got me through the golf season. He then suggested a total hip replacement and after surgery I was up and walking the next day with little discomfort. I was able to go home in less than 2 days. I am now looking forward to getting my left hip replaced. Thanks to Dr. O’Keefe for everything.
February 24, 2017
I am so grateful for Dr. O’Keefe and his staff. I had injections in my knees that helped immensely! I appreciate the time he takes to explain the options available. I am hopeful that the injections will be all I need, however, if I need further interventions, he is the one I will return to! The front desk staff, X-ray techs and his assistant are very friendly and made me feel comfortable. Hats OFF to Dr. O’Keefe and his entire team!!
December 21, 2016
After Dr. O’Keefe performed an MRI on me, he told me that the only help was surgery. Dr. O’Keefe has excellent relations with the patients. In August 2016, I saw him 4 weeks after surgery and he ordered 4 weeks of therapy. I had therapy twice a week and did my therapy on days that I didn’t have therapy scheduled. By November, I was at 100%. I am now in Florida trap shooting and playing golf weekly. Thanks again for a great job.
December 16, 2016
While taking part in an obstacle course mid-September, I suffered a shoulder injury, specifically a dislocated shoulder. After an immediate trip to the emergency room to have my shoulder placed back into the socket, I had to make an appointment to see an orthopedic physician to explore some options. This is when I met Dr. O’Keefe. I explained my situation to him and he had me schedule an MRI, concerned there may be additional damage to the injury site. He was correct. I had also torn my labrum. Again, it was time to explore some options. Surgery was not on my list of things I wanted to do, but Dr. O’Keefe explained it was the best avenue for me and more importantly, why. In a few minutes, Dr. O’Keefe reminded me of the meaningful things in life, which was significant because he spoke of my family, all while my wife and kids were in the room. I agreed to have surgery, followed by physical therapy. Dr. O’Keefe performed the procedure on me, which was a success. While I was in recovery, Dr. O’Keefe went to fill my wife in on how it had gone and said to call with any questions or concerns. This made me feel like I was the only patient Dr. O’Keefe had since it seemed as though he had committed so much time and effort on me since I had first went to see him. Following surgery, the team of physical therapists at Twin Cities Orthopedics in Otsego treated me with dignity and respect. All in all, this mishap, which was not planned, intentional, or desired, gave me the opportunity to meet some great people who had genuine compassion and sincere interest to get me back to normal. I would profoundly recommend having Dr. O’Keefe and the team(s) at Twin Cities Orthopedics facilitate your orthopedic needs.
February 11, 2016
My knee replacement has been a journey from knee pain, orthoscopic meniscus repair surgery, cortisone shots and finally full left knee replacement. Dr. O’Keefe and his team have been with me through all steps, answering questions, offering support and finally helping make the decision to replace a very worn out knee joint. The decision was mine made on the facts that the knee joint and pain was affecting the quality of my life. I am 72 years old and have places to go, things to do, a loving, supportive husband, children and grandchildren, with whom I want to share my life, not observing from the sidelines.
I strongly recommend attending the recommended pre-operation seminar that gives you a great overview of the hospital stay and process. Do the exercises daily leading up to the surgery and after! Ask questions.
My surgery was on a Wednesday and I was home, with help from my husband, on Friday. Physical therapy in the hospital, at home, and at the clinic has enabled me to walk without a cane at home, except on stairs, within 3 weeks and slowly ride a stationary bike, only for 5 minutes within 4 weeks after the surgery. All of this success is due to the wonderful, positive, supportive team that works with Dr. O’Keefe and Twin Cities Orthopedics. I totally believe that my successful recovery is due to this team and would highly recommend them to anyone with knee joint pain. I had arthritis in the joint and no meniscus. They dealt with all of this and I could not be happier!
January 8, 2016
Dr. O’Keefe has been my go to physician for many surgeries. He is an incredibly dependable physician and is always happy to answer questions when he is available. Candice and his care team are fantastic! Dr. O’Keefe is a kind man with great bedside manner. He never rushes appointments and does not keep patients waiting long. I would and have recommended him to many people I know considering operations. I would rate Dr. O’Keefe an 11 on a scale 1-10! Cannot say enough great things!
January 2, 2015
Dr. O’Keefe did an excellent job of repairing my broken elbow that resulted from a bicycle accident. The follow up was appropriate. I completed occupational therapy at Twin Cities Orthopedics with good results.