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Nicholas N. Holmes, MD

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Family Medicine, Board Certified Primary Care Sports Medicine Fellowship Sports Medicine Subspecialty Certification

Appointment Info

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Areas of Focus

Foot & Ankle Care
Hand & Wrist Care
Hip Care
Knee Care
Pediatric Care
Shoulder & Elbow Care
Spine & Neck Care
Sports Concussion
Sports Medicine

Nicholas N. Holmes, MD

Practice Overview

Nicholas N. Holmes, MD, is a board certified primary care sports medicine provider who specializes in musculoskeletal injuries and conditions (bone health), ultrasound-guided injections, ultrasound, and concussion management.

Clinical Interest

Non-operative orthopedics

Sports medicine, including family medicine, sports medicine, platelet-rich plasma (PRP) injections, and concussion management

Ankle care

Bone health 

Elbow care

Foot care

Hip care

Knee care

Spine care

Shoulder care


Board Certified, American Board of Family Medicine
Subspecialty Certification in Sports Medicine

Primary Care Sports Medicine, AnMed Health, Anderson, South Carolina

St. Joseph Mercy Oakland Hospital, Pontiac, Michigan; AnMed Health, Anderson, South Carolina,
Seneca Lakes Family Medicine Program – Oconee Medical Center, Seneca, South Carolina

Medical Degree
St. George’s University, Grenada

Professional Affiliations

American Academy of Family Physicians
American Medical Society for Sports Medicine
Wilderness Medical Society

Sports Affiliations

Team Physician: Park High School


Jill G.

Patient Testimonials

August 4, 2021

Diane C.

I have been going to Dr. Holmes for years. He has given me cortisone shots, when necessary, for extreme pain on separate knees multiple times. I had one knee replaced 3 years ago and the other is now getting worse but we are trying to avoid surgery. Holmes is absolutely, hands-down the best shot giver I have ever encountered. He listens and provides alternative solutions with thorough explanations before we proceed. Even his assistant, Deanna, is top notch and a great listener. His sensitivity and shot-giving techniques are A+. It feels great! Wow!

November 6, 2019

Hayley P.

I spent my junior year of high school in constant pain because of my shoulder injury. I saw several doctors to get help with the pain and tried everything from physical therapy, acupuncture and massage. My shoulder pain continued to get worse. I got to the point that I could not concentrate at school because of the pain and I had to quit basketball. With cortisone shots I was able to play softball but I was still in significant pain. After the platelet rich plasma (PRP) injection, I was soon able to get the full range of motion back in my shoulder. I am fully enjoying my senior year pain-free. I am 3 weeks into the softball season and still completely pain free in my shoulder. I wish I would have had the PRP injection much sooner. Thank you, Dr. Holmes!

December 28, 2018

Tom A.

My husband has suffered with Parkinson’s Disease since he was 44 years old. The constant shaking for 13 years has damaged his knee and shoulder joints, causing extreme pain. He is not a surgical candidate and refuses all opioid pain meds. Dr. Holmes injects his joints a few times a year, which has enabled my husband to still enjoy fishing and hunting. Thank you Dr. Holmes!

May 9, 2016

Rebecca P.

After a hockey injury left her with chronic knee pain, Rebecca sought treatment with Dr. Nicholas Holmes of Twin Cities Orthopedics. She underwent a PRP (plasma-rich platelet) injection and was able to recover from her pain completely. As Rebecca puts it, “Twin Cities Orthopedics took my pain away.”

Click here to watch Rebecca’s story

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Nicholas N. Holmes, MD